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pentobarbital will lessen the extent or influence of elbasvir/grazoprevir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic influence of elbasvir/grazoprevir could possibly be minimized if coadministered with sturdy CYP3A inducers and is also thus contraindicated.fentanyl intranasal and pentobarbital both